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Ekins Sean The Agile Approach to Adaptive - priemnaya33.ru
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Ekins Sean The Agile Approach to Adaptive Research. Optimizing Efficiency in Clinical Development


Apply adaptive research to improve results in drug development The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently. With a wealth of real-world cases and examples, author Michael Rosenberg gives readers a practical overview of drug development, the problems inherent in current practices, and the advantages of adaptive research technology and methods. He explains the concepts, principles, and specific techniques of adaptive research, and demonstrates why it is an essential evolutionary step toward improving drug research and development. Chapters explore such subjects as: The adaptive concept Design and operational adaptations Sample-size reestimation Agile clinical development Safety and dose finding Statistics in adaptive research, including frequentist and Bayesian approaches Data management technologies The future of clinical development By combining centuries-old intellectual foundations, recent technological advances, and modern management techniques, adaptive research preserves the integrity and validity of clinical research but dramatically improves efficiency.

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Группа авторов PMI-ACP Project Management Institute Agile Certified Practitioner Exam Study Guide


The ultimate study package for the new PMI-ACP exam The PMI-ACP Project Management Institute Agile Certified Practitioner Exam Study Guide is an all-in-one package for comprehensive exam preparation. This up-to-date guide is fully aligned with the latest version of the exam, featuring coverage of 100 percent of the exam domains. Expanded coverage of AGILE includes the basic principles, value-driven delivery, stakeholder engagement, team performance, adaptive planning, problem detection and resolution, and continuous improvement to align with the A Guide to the Project Management Body of Knowledge (PMBOK® 6th Edition) and its increased emphasis on agile, adaptive and iterative practices. In-depth discussion merges with hands-on exercises and real-world scenarios to provide a well-rounded review of essential exam concepts, while the online learning center provides an assessment test, chapter tests, a practice exam, and study aids to help you ensure complete preparation for the big day. Master 100 percent of the exam objectives, including expanded AGILE coverage Reinforce critical concepts with hands-on practice and real-world scenarios Test your knowledge with challenging chapter review questions One year of FREE access to the Sybex online test bank featuring practice tests, flashcards, a glossary, and more Project management is one of the most in-demand skills in today's job market, making more and more employers turn to AGILE methodologies to enhance delivery and results. The PMI-ACP certification shows employers that you have demonstrated mastery of essential project management skills and a practical understanding of adaptive, iterative processes; this validation puts you among the ranks of qualified project management professionals employers are desperately seeking, and the PMI-ACP Project Management Institute Agile Certified Practitioner Exam Study Guide is your one-stop resource for exam success.

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Bernard Widrow Adaptive Inverse Control, Reissue Edition


A self-contained introduction to adaptive inverse control Now featuring a revised preface that emphasizes the coverage of both control systems and signal processing, this reissued edition of Adaptive Inverse Control takes a novel approach that is not available in any other book. Written by two pioneers in the field, Adaptive Inverse Control presents methods of adaptive signal processing that are borrowed from the field of digital signal processing to solve problems in dynamic systems control. This unique approach allows engineers in both fields to share tools and techniques. Clearly and intuitively written, Adaptive Inverse Control illuminates theory with an emphasis on practical applications and commonsense understanding. It covers: the adaptive inverse control concept; Weiner filters; adaptive LMS filters; adaptive modeling; inverse plant modeling; adaptive inverse control; other configurations for adaptive inverse control; plant disturbance canceling; system integration; Multiple-Input Multiple-Output (MIMO) adaptive inverse control systems; nonlinear adaptive inverse control systems; and more. Complete with a glossary, an index, and chapter summaries that consolidate the information presented, Adaptive Inverse Control is appropriate as a textbook for advanced undergraduate- and graduate-level courses on adaptive control and also serves as a valuable resource for practitioners in the fields of control systems and signal processing.

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Marios Polycarpou M. Adaptive Approximation Based Control


A highly accessible and unified approach to the design and analysis of intelligent control systems Adaptive Approximation Based Control is a tool every control designer should have in his or her control toolbox. Mixing approximation theory, parameter estimation, and feedback control, this book presents a unified approach designed to enable readers to apply adaptive approximation based control to existing systems, and, more importantly, to gain enough intuition and understanding to manipulate and combine it with other control tools for applications that have not been encountered before. The authors provide readers with a thought-provoking framework for rigorously considering such questions as: * What properties should the function approximator have? * Are certain families of approximators superior to others? * Can the stability and the convergence of the approximator parameters be guaranteed? * Can control systems be designed to be robust in the face of noise, disturbances, and unmodeled effects? * Can this approach handle significant changes in the dynamics due to such disruptions as system failure? * What types of nonlinear dynamic systems are amenable to this approach? * What are the limitations of adaptive approximation based control? Combining theoretical formulation and design techniques with extensive use of simulation examples, this book is a stimulating text for researchers and graduate students and a valuable resource for practicing engineers.

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Andreas Opelt Agile Contracts


A methodologically sophisticated, comprehensive approach to applying the Agile fixed-price contract to IT projects while maximizing customer and supplier relationships «Interesting and necessary for IT managers and IT lawyers.» —Walter J. Jaburek, Dipl.-Ing., Dr. iur., Dr. techn. Approximately 50 percent of software developers use Scrum, an iterative and incremental development method for managing software projects and product or application development, in their work. The benefit of Scrum and other Agile methods is that they can address shifts in a large project that traditional managerial methods cannot. Written by pioneers and leaders in the field of Agile and Scrum, Agile Contracts is the only book dedicated exclusively to the legal, procurement, and project management considerations of Agile contracts. Providing templates, a toolbox, and examples of Agile fixed-price contracts, the book presents an alternative option to fixed-price, time-based, and supply-based contracts—reducing the risk for both the supplier and the customer with a contract that offers the possibility of flux and flexible scenarios as a project progresses. Agile Contracts features in-depth chapter coverage of: The Agile Manifesto of 2001 Agility from the perspective of procurement and the software provider The problems with traditional fixed-price contracts and time material contracts What the Agile fixed-price contract is and how it is set up Tendering based on the Agile fixed-price contract How to negotiate an Agile fixed-price contract Special guidelines for the legal framework of an Agile fixed-price contract Adaptable Scope System The Black Swan scenario Contracts and procedures for the featured methodologies Especially applicable within highly structured business organizations, Agile Contracts is a must-read for project managers, agile practitioners, procurement representatives, and IT lawyers.

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Charles Cobb G. Making Sense of Agile Project Management. Balancing Control and Agility


The book is intended to provide a much deeper understanding of agile principles, methodologies, and practices to enable project managers to develop a more agile approach and understand how to blend and tailor agile and traditional principles, methodologies, and practices to create an appropriate balance of control and agility to fit a business environment as well as the risks and complexities of any individual project. The book will also provide business managers and leaders an understanding of how to fit agile methodologies into an overall business strategy that provides the right balance of control and agility for their business.

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Adam Butler Adaptive Asset Allocation. Dynamic Global Portfolios to Profit in Good Times - and Bad


Build an agile, responsive portfolio with a new approach to global asset allocation Adaptive Asset Allocation is a no-nonsense how-to guide for dynamic portfolio management. Written by the team behind Gestaltu.com, this book walks you through a uniquely objective and unbiased investment philosophy and provides clear guidelines for execution. From foundational concepts and timing to forecasting and portfolio optimization, this book shares insightful perspective on portfolio adaptation that can improve any investment strategy. Accessible explanations of both classical and contemporary research support the methodologies presented, bolstered by the authors' own capstone case study showing the direct impact of this approach on the individual investor. Financial advisors are competing in an increasingly commoditized environment, with the added burden of two substantial bear markets in the last 15 years. This book presents a framework that addresses the major challenges both advisors and investors face, emphasizing the importance of an agile, globally-diversified portfolio. Drill down to the most important concepts in wealth management Optimize portfolio performance with careful timing of savings and withdrawals Forecast returns 80% more accurately than assuming long-term averages Adopt an investment framework for stability, growth, and maximum income An optimized portfolio must be structured in a way that allows quick response to changes in asset class risks and relationships, and the flexibility to continually adapt to market changes. To execute such an ambitious strategy, it is essential to have a strong grasp of foundational wealth management concepts, a reliable system of forecasting, and a clear understanding of the merits of individual investment methods. Adaptive Asset Allocation provides critical background information alongside a streamlined framework for improving portfolio performance.

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Rachel Alt-Simmons Agile by Design. An Implementation Guide to Analytic Lifecycle Management


Achieve greater success by increasing the agility of analytics lifecycle management Agile by Design offers the insight you need to improve analytic lifecycle management while integrating the right analytics projects into different frameworks within your business. You will explore, in-depth, what analytics projects are and why they are set apart from traditional development initiatives. Beyond merely defining analytics projects, Agile by Design equips you with the information you need to apply agile methodologies in a way that tailors your approach to individual initiatives—and the needs of your projects and team. Lifecycle management is a complex subject area, and with the increasingly important integration of analytics into multiple facets of business models, understanding how to use agile tools while managing a product lifecycle is essential to maintaining a competitive edge in today's professional world. Gain an understanding of the principles, processes, and practices associated with effective analytic lifecycle management Discover techniques that will enable you to successfully initiate, plan, and execute analytic development projects with an eye for the opportunity to engage agile methodologies Understand agile development frameworks Identify which agile methodologies are best for different frameworks—and how to apply them throughout the analytic development lifecycle With analytics becoming increasingly important in today's business world, you need to understand and apply agile methodologies in order to meet rising standards of efficiency and effectiveness. Agile by Design is the perfect reference for project managers, CFOs, IT managers, and marketing managers who want to cultivate a relevant, forward-thinking lifecycle management style.

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David Wagg Adaptive Structures


Adaptive structures have the ability to adapt, evolve or change their properties or behaviour in response to the environment around them. The analysis and design of adaptive structures requires a highly multi-disciplinary approach which includes elements of structures, materials, dynamics, control, design and inspiration taken from biological systems. Development of adaptive structures has been taking place in a wide range of industrial applications, but is particularly advanced in the aerospace and space technology sector with morphing wings, deployable space structures; piezoelectric devices and vibration control of tall buildings. Bringing together some of the foremost world experts in adaptive structures, this unique text: includes discussions of the application of adaptive structures in the aerospace, military, civil engineering structures, automotive and MEMS. presents the impact of biological inspiration in designing adaptive structures, particularly the use of hierarchy in nature, which typically induces multi-functional behavior. sets the agenda for future research in adaptive structures in one distinctive single volume. Adaptive Structures: Engineering Applications is essential reading for engineers and scientists working in the fields of intelligent materials, structural vibration, control and related smart technologies. It will also be of interest to senior undergraduate and postgraduate research students as well as design engineers working in the aerospace, mechanical, electrical and civil engineering sectors.

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Woon-Seng Gan Subband Adaptive Filtering


Subband adaptive filtering is rapidly becoming one of the most effective techniques for reducing computational complexity and improving the convergence rate of algorithms in adaptive signal processing applications. This book provides an introductory, yet extensive guide on the theory of various subband adaptive filtering techniques. For beginners, the authors discuss the basic principles that underlie the design and implementation of subband adaptive filters. For advanced readers, a comprehensive coverage of recent developments, such as multiband tap–weight adaptation, delayless architectures, and filter–bank design methods for reducing band–edge effects are included. Several analysis techniques and complexity evaluation are also introduced in this book to provide better understanding of subband adaptive filtering. This book bridges the gaps between the mixed–domain natures of subband adaptive filtering techniques and provides enough depth to the material augmented by many MATLAB® functions and examples. Key Features: Acts as a timely introduction for researchers, graduate students and engineers who want to design and deploy subband adaptive filters in their research and applications. Bridges the gaps between two distinct domains: adaptive filter theory and multirate signal processing. Uses a practical approach through MATLAB®-based source programs on the accompanying CD. Includes more than 100 M-files, allowing readers to modify the code for different algorithms and applications and to gain more insight into the theory and concepts of subband adaptive filters. Subband Adaptive Filtering is aimed primarily at practicing engineers, as well as senior undergraduate and graduate students. It will also be of interest to researchers, technical managers, and computer scientists.

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The Agile Approach to Adaptive Research: Optimizing ...

The Agile Approach to Adaptive Research: Optimizing Efficiency in Clinical Development (Wiley Series on Technologies for the Pharmaceutical Industry) | Ekins, Sean, Rosenberg, Michael J. | ISBN: 9780470599686 | Kostenloser Versand für alle Bücher mit Versand und Verkauf duch Amazon.

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The End of Agile - Forbes

Agile is a powerful methodology but in an increasingly data-driven world, it may not necessarily be ...[+] the right one. Getty. I knew the end of Agile was coming when we started using hockey sticks.

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Michael J. Rosenberg, Sean Ekins (Series Editor) ISBN: 978-0-470-59967-9. 304 pages. February 2010. Description. Apply adaptive research to improve results in drug development. The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business, the development of new drugs. The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research ...

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The Agile Approach to Adaptive Research

Edited by Sean Ekins and Jinghai J. Xu . The Engines . of . Hippocrates: From the Dawn . of . Medicine to Medical and . Barry Robson and O.K. Baek . Pharmaceutical Data Mining: Approaches andApplications for Drug Discovery . Edited by Konstantin V. Balakin . The Agile Approach to Adaptive Research: Optimizing Eficiency in . Michael J. Rosenberg . Environmental Chemicals Applications ...

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Sean Ekins - Wikipedia

Sean Ekins is a British pharmacologist and expert in the fields of ADME/Tox, computational toxicology and cheminformatics at Collaborations in Chemistry, a division of corporate communications firm Collaborations in Communications. He is also the editor of four books and a book series for John Wiley & Sons. Biography. Sean Ekins was born in Cleethorpes, England, on 2 March 1970 to John Ekins ...

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By Sean Ekins and Michael J. Rosenberg and Michael J. J. Rosenberg. Medical : Pharmacology | Medical : Pharmacy. Wiley Publication date: February 2010. ISBN: 9780470599679 Digital Book format: PDF (Adobe DRM) Buy PDF. Our price: $ 77.99. Apply adaptive research to improve results in drug development. The pharmaceutical industry today faces a deepening crisis: inefficiency in its core business ...

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The Agile Approach to Adaptive Research pdf | Medical Books

The Agile Approach to Adaptive Research offers a solution. It outlines how adaptive research, using already-available tools and techniques, can enable the industry to streamline clinical trials and reach decision points faster and more efficiently. With a wealth of real-world cases and examples, author Michael Rosenberg gives readers a practical overview of drug development, the problems ...

Agile Vs. Lean: Yeah Yeah, What’s the Difference? - Abby ...

Agile refers to a set of values and principles put forth in the Agile Manifesto. The Manifesto was a reaction against heavyweight methodologies that were popular, yet crippling software projects from actually doing what they needed to do – create software that helped the customer! I believe Agile’s values & principles work

Ekins, Sean | Tekijä | Ellibs E-kirjakauppa

Ekins, Sean. 143,90€ Computer Applications in Pharmaceutical Research and Development ... The Agile Approach to Adaptive Research: Optimizing Efficiency in Clinical Development. Rosenberg, Michael J. 70,60€ The Engines of Hippocrates: From the Dawn of Medicine to Medical and Pharmaceutical Informatics ...

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Sean Ekins, MSc, PhD, DSc has over 20 years of pharmaceutical and toxicology experience. He is the founder or co-founder of two companies and Adjunct Professor at three universities. He has been awarded 15 NIH grants as Principal Investigator. He ...

Sean Ekins — COVID-19 Research Collaborations

Sean Ekins. 10/06/20. 1 item of Media coverage. Press/Media. Shinpoong, Bukwang stocks jump on Covid-19 drug ca... Sean Ekins. 11/05/20. 2 items of Media coverage. Press/Media. Remdesivir Has Therapeutic Potential against SARS-CoV-2 Coronavirus, Scientists Say. Peter B. Madrid & Sean Ekins. 1/04/20. 1 item of Media coverage . Press/Media. Powered by Pure, Scopus & Elsevier Fingerprint Engine ...

‪sean ekins‬ - ‪Google Scholar‬

sean ekins. Collaborations Pharmaceuticals, Inc. Verified email at collaborationspharma.com - Homepage. drug discovery rare diseases neglected diseases machine learning. Articles Cited by Co-authors. Title. Sort. Sort by citations Sort by year Sort by title. Cited by. Cited by. Year; In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling. S Ekins, J ...

ChemSpider | Data Source Details | Sean Ekins

Sean Ekins areas of interest are in vitro and computational ADME/Tox, Systems Biology, informatics and computer-aided drug discovery. Sean has joined the advisory board to promote the use of ChemSpider to pharmacologists, using the tool to inform SAR and drug discovery research. He has worked as a senior scientist at Pfizer, Lilly Research Laboratories, Concurrent Pharmaceuticals, Inc. and ...

sean ekins: 13 Books available | chapters.indigo.ca

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Suchergebnisse - eBooks bei buchmaXx

Pharmaceutical and Biomedical Project Management in a Changing Global Environment von: Scott D. Babler, Sean Ekins

Sean Ekins (Author of Computer Applications in ...

Sean Ekins is the author of Computer Applications in Pharmaceutical Research and Development (4.00 avg rating, 9 ratings, 1 review, published 2006), Coll...

Suchergebnisse - Wiley-VCH eBooks

Pharmaceutical and Biomedical Project Management in a Changing Global Environment von: Scott D. Babler, Sean Ekins

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View the profiles of people named Sean Ekins. Join Facebook to connect with Sean Ekins and others you may know. Facebook gives people the power to share...

dblp: Sean Ekins

List of computer science publications by Sean Ekins. ORCID. ID inferred from metadata, verification pending. 0000-0002-5691-5790

Computer Applications in Pharmaceutical Research and ...

Sean Ekins (Editor) really liked it 4.00 · Rating details · 9 ratings · 1 review A unique, holistic approach covering all functions and phases of pharmaceutical research and development While there are a number of texts dedicated to individual aspects of pharmaceutical research and development, this unique contributed work takes a ...

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Till Bay Co-Pilot


This book describes the agile software development process of Comerge AG from Zürich, Switzerland. Founded 2008 as a startup with four employees, the team consists now of over twenty members. Embracing an agile approach from the beginning, the Comergers have developed a lightweight yet efficient project management toolkit which lead to the successful release of more than 280 projects for over twenty clients. Covering the SCRUM approach, the Co-Pilot helps you focus on efficient and elementary project management techniques. It serves as a guideline to keeping the customer in the loop and particularly focuses on the often underestimated „Testing“ part of the agile software delivery process.

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Hugh Beyer User-Centered Agile Methods


With the introduction and popularization of Agile methods of software development, existing relationships and working agreements between user experience groups and developers are being disrupted. Agile methods introduce new concepts: the Product Owner, the Customer (but not the user), short iterations, User Stories. Where do UX professionals fit in this new world? Agile methods also bring a new mindset – no big design, no specifications, minimal planning – which conflict with the needs of UX design.


This lecture discusses the key elements of Agile for the UX community and describes strategies UX people can use to contribute effectively in an Agile team, overcome key weaknesses in Agile methods as typically implemented, and produce a more robust process and more successful designs. We present a process combining the best practices of Contextual Design, a leading approach to user-centered design, with those of Agile development.


Table of Contents: Introduction / Common Agile Methods / Agile Culture / Best Practices for Integrating UX with Agile / Structure of a User-Centered Agile Process / Structuring Projects / Conclusion

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Phil Simon Analytics. The Agile Way


For years, organizations have struggled to make sense out of their data. IT projects designed to provide employees with dashboards, KPIs, and business-intelligence tools often take a year or more to reach the finish line…if they get there at all. This has always been a problem. Today, though, it's downright unacceptable. The world changes faster than ever. Speed has never been more important. By adhering to antiquated methods, firms lose the ability to see nascent trends—and act upon them until it's too late. But what if the process of turning raw data into meaningful insights didn't have to be so painful, time-consuming, and frustrating? What if there were a better way to do analytics? Fortunately, you're in luck… Analytics: The Agile Way is the eighth book from award-winning author and Arizona State University professor Phil Simon. Analytics: The Agile Way demonstrates how progressive organizations such as Google, Nextdoor, and others approach analytics in a fundamentally different way. They are applying the same Agile techniques that software developers have employed for years. They have replaced large batches in favor of smaller ones…and their results will astonish you. Through a series of case studies and examples, Analytics: The Agile Way demonstrates the benefits of this new analytics mind-set: superior access to information, quicker insights, and the ability to spot trends far ahead of your competitors.

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Ashish Tewari Adaptive Aeroservoelastic Control


This is the first book on adaptive aeroservoelasticity and it presents the nonlinear and recursive techniques for adaptively controlling the uncertain aeroelastic dynamics Covers both linear and nonlinear control methods in a comprehensive manner Mathematical presentation of adaptive control concepts is rigorous Several novel applications of adaptive control presented here are not to be found in other literature on the topic Many realistic design examples are covered, ranging from adaptive flutter suppression of wings to the adaptive control of transonic limit-cycle oscillations

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Sandra Marton The One-Night Wife


The bride-to-be…Penniless Savannah knows that to help her sick little sister she has to win big at the casino.The groom…But Sean O'Connell always plays to win…The indecent proposal…Virgin Savannah is no match for Sean and soon she's lost everything! Sean offers her one last gamble: he'll settle her debts if she becomes his wife…for just one night!

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Thomas O'Gorman W. Adaptive Tests of Significance Using Permutations of Residuals with R and SAS


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